【摘要】 背景与目的:慢性丙型肝炎病毒(hepatitis C virus,HCV)感染率近年来逐渐升高,其合并肝细胞癌的发病率也不断上升。基于此原因,本文对HCV感染合并肝细胞癌(hepatocellular carcinoma,HCC)患者(HCV-HCC)的临床特征进行研究。方法:回顾性分析2002年3月至2006年3月期间接受根治性手术HCC合并HCV感染的64例患者的资料,并选择同期手术的乙型肝炎病毒(hepatitis B virus,HBV)感染合并HCC(HBV-HCC)100例患者作为对照组,行病例对照研究,比较2组患者手术并发症和术后情况。结果:HCV-HCC组患者诊断时平均年龄为(61.7±9.6)岁,肝硬化发生率为90.6%,术后严重并发症的发生率为14.1%,均显著高于对照组(P<0.05);尽管HCV-HCC的患者术后1年复发率与对照组相当,但死亡率显著较高(P=0.038)。结论:对于HCV-HCC的患者,术前宜谨慎评估,术后应强化护肝治疗以降低手术并发症,以提高术后生存率。更多还原

【Abstract】 Background and purpose:The incidence of hepatitis C virus(HCV) infection is increasing worldwide.This paper was to study the clinical features of HCV-related hepatocellular carcinoma(HCV-HCC).Methods:We retrospectively analyzed the clinical data from the patients with HCC who underwent curative liver resection and randomly selected 64 patients with HCV infection and 100 patients with hepatitis B virus(HBV) infection as a control group.Post-operative complications and early prognosis were studied.Results:As compared with the patients with HBV-HCC,average age,incidence of liver cirrhosis and complications were signifi cantly higher in the patients with HCV-HCC(P<0.05).One-year survival rate of the HCV-HCC patients was lower than that of the HBV-HCC patients(P=0.038),although 1-year recurrence rate has no difference between them.Conclusion:HCV-HCC patients should be carefully evaluated to be selected for curative resection and intensively care should be given after surgery.更多还原