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影响子宫内膜癌预后的高危因素分析

Analysis on high risk factors of endometrial carcinoma prognosis

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【作者】 杨越波叶敏娟沈慧敏丁淼张永裕

【Author】 YANG Yue-Bo,YE Min-Juan,SHEN Hui-Min et al.Department of Gynecology,the Third Affiliated Hospital of SUN Yat-Sen University,Guangzhou 510630,Guangdong,China

【机构】 中山大学附属第三医院妇科中山大学附属第二医院妇产科

【摘要】 目的:回顾性分析总结影响子宫内膜癌预后的高危因素。方法:对2000年12月~2004年12月中山大学附属第三医院、中山大学附属第二医院及中山大学附属肿瘤医院妇科收治的189例子宫内膜癌病例进行回顾性分析,进一步探讨病理类型、组织学分级、肌层浸润深度、淋巴结转移、手术病理分期、合并症与预后之间的关系。结果:手术病理分期、不同病理类型、组织学分级、有无肌层浸润和淋巴结转移中患者的生存曲线比较,结果均P<0.05,差异有统计学业意义;有无合并糖尿病、高血压或肥胖患者的生存曲线比较,结果均P>0.05,差异无统计学意义。COX回归多因素分析,组织学分级与肌层浸润深度对生存时间的影响差异有统计学意义(P<0.05)。结论:特殊病理类型、组织学低分化、深肌层浸润、淋巴结转移、期别晚是提示预后不良的高危因素。

【Abstract】 Objective:To summarize the high risk factors of endometrial carcinoma prognosis.Methods:189 cases of endometrial carcinoma from three hospitals were analyzed retrospectively from December 2000 to December 2004,the relationships between pathologic types,histologic grading,myometrial invasion depth,lymphatic metastasis,surgical-pathologic staging,complications and prognosis were explored.Results:There was significant difference in survival curves between different surgical-pathologic stagings,pathologic types,histologic gradings,different depths of myometrial invasion and lymphatic metastasis or not(P<0.05).There was no difference in survival curves between cases with diabetes or not,hypertension or not and obesity or not(P>0.05).Multivariate analysis indicated that histologic grading and depth of myometrial invasion were independent high risk factors for prognosis of endometrial carcinoma(P<0.05).Conclusion:Special pathologic types,low histological grading,deep myometrial invasion,lymphatic metastasis,late pathologic staging are high risk factors of endometrial carcinoma prognosis.

【关键词】 子宫内膜癌高危因素预后
【Key words】 Endometrial carcinomaHigh risk factorPrognosis
【基金】 国家自然科学基金(30772332);广东省自然科学基金(7001568);广东省科技计划项目(2007B030502014);广州市科技计划项目(2007Z3-E0601)资助
  • 【文献出处】 中国妇幼保健 ,Maternal and Child Health Care of China , 编辑部邮箱 ,2009年23期
  • 【分类号】R737.33
  • 【被引频次】8
  • 【下载频次】288
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