【摘要】 目的:探讨多囊卵巢综合征(PCOS)患者血清脂联素(APN)与胰岛素抵抗(IR)的相关性。方法:以PCOS患者58例为研究组,同期非PCOS患者37例为对照组,按照体重指数(BMI)均分为BMI≥23、BMI<23两组,按照胰岛素抵抗指数(HOMA-IR)将研究组再分为胰岛素抵抗组和非胰岛素抵抗组,测定血清APN、胰岛素、性激素。结果:①研究组血清APN水平低于对照组(P=0.001),空腹胰岛素水平(Fins)、HOMA-IR高于对照组(P均<0.001)。②BMI与HOMA-IR呈正相关(r=0.544,P<0.001),与血清APN水平呈负相关(r=-0.392,P<0.001),研究组和对照组的BMI≥23组的血清APN水平均低于BMI<23组(P=0.001,P<0.05)。③研究组血清APN水平与HOMA-IR呈负相关(r=-0.346,P<0.001),控制BMI后血清APN水平与HOMA-IR无明显相关性(r=-0.240,P>0.05)。结论:PCOS患者存在明显胰岛素抵抗和低脂联素血症,血清APN水平降低与PCOS患者肥胖相关的胰岛素抵抗有关。更多还原

【Abstract】 Objective:To explore the correlation between adiponectin in serum and insulin resistance in women with polycystic ovary syndrome (PCOS).Methods:58 women diagnosed as PCOS (case group) and 37 healthy women (control group) were selected and divided into BMI≥23 group and BMI<23 group respectively according to the body mass index, case group was divided into insulin resistance group and non-insulin resistance group according to the insulin resistance index (HOMA-IR).The levels of adiponectin,insulin and sex hormones in serum were detected in four groups.Results:①The level of adiponectin in case group was lower than that in control group (P=0.001), while the levels of fasting insulin and HOMA-IR were higher than those in control group (P<0.001).②There was positive correlation between BMI and HOMA-IR (r=0.544,P<0.001),but there was negative correlation between BMI and adiponectin (r=-0.392,P<0.001),the levels of adiponectin in serum of BMI≥23 groups were lower than those of BMI<23 group in case group and control group (P=0.001,P<0.05).③There was negative correlation between adiponectin and HOMA-IR in case group (r=-0.346,P<0.001),but after controlling the influennce of BMI,the significance disappeared(r=-0.240,P>0.05).Conclusion:Insulin resistance and hypoadiponectin exist in PCOS patients and hypoadiponectin is related to obesity-related insulin resistance in PCOS patients.更多还原