【摘要】 目的观察恶性肿瘤合并慢性HBV携带者化疗后HBV再激活情况。方法常规方法检测慢性HBV携带者化疗前后肝功能及乙肝标志物,荧光聚合酶链反应法检测HBV-DNA变化情况。结果84例肿瘤合并慢性HBV携带患者,其中50例化疗后出现HBV再激活伴肝功能异常,需保肝治疗,推迟甚至终止了化疗。结论对于需要化疗的HBV携带者,除监测肝功能外,应常规检测HBV-DNA。更多还原

【Abstract】 Objective To observe HBV reactivation in the cases of malignant tumor with chronic HBV carrying after chemotherapy.Methods We used conventional methods to detect the liver function and hepatitis B markers,and fluorescent polymerase chain reaction(PCR)to detect HBV-DNA changes in chronic HBV carriers before and after chemotherapy.Results Fifty in 84 cases of malignant tumor with chronic HBV carrying showed HBV activation with abnormal liver functions after chemotherapy.The chemotherapy had to be postponed or even terminated due to liver protective treatment.Conclusion Besides the monitoring of the liver functions,the routine detection of HBV-DNA should be carried out in the cases of the malignant tumor with chronic HBV carrying in case of chemotherapy.更多还原