【摘要】 目的探讨腹膜胶质瘤病(GP)的发生、临床病理特征及预后。方法对1例GP进行组织形态学、免疫组化分析,并复习相关国内、外文献。结果患者女性,10岁。腹胀2个月。CT示中腹部双肾前见一类圆形巨大混杂性肿块影。术中见肿瘤21cm×18cm×7cm大小,包膜完整,表面被覆大网膜,肿物及大网膜表面满布直径0.1～0.5cm的灰白色小结节。镜下肿物由成熟三胚层组织组成,含大量神经胶质组织。大网膜和肿瘤包膜上密集的粟粒样结节,镜下均为成熟神经胶质组织,边界清楚,无浸润。免疫组化:腹膜神经胶质结节GFAP、S-100和vimentin(+),结节表面被覆的间皮细胞CK(+)。结论GP是一种罕见病症,大部分对预后无不良影响,但可有恶变,需长期随访。组织起源尚需大宗研究。更多还原

【Abstract】 Objective To study the pathogenesis,clinicopathological features and prognosis of gliomatosis peritonei(GP).Methods A case of GP was analyzed by light microscopy and immunohistochemistry and related literatures were reviewed.Results A 10-year-old girl presented with abdominal distension.CT showed a huge cystic and solid mass in the abdominal cavity.Macroscopically,the tumor measured 21?cm× 18?cm× 7?cm with intact capsule and local adhesion of omentum.Neumerous,grey-white nodules,0.1?cm to 0.5?cm in diameter,were noted on the surface of the tumor and omentum.Microscopically,the ovary tumor was composed of mature epidermal,mesodermal and endodermal elements with large amount of glial tissue.Numerous omental nodules were composed of mature glial tissue.Immunohistochemically,glial fibrillary acid protein(GFAP),S-100 protein,vimentin were positive in the mature glial tissue.Cytokeratin was positive in the mesothelial cells covering the nodules.Conclusion GP is an extremely rare condition which has no adverse effect on the prognosis,but needs a long-term follow-up because of its potential of malignant transformation.更多还原