【摘要】 目的研究肾茶Clerodendranthus spicatus水溶性部位的化学成分。方法采用硅胶、反相硅胶ODS-A、Sephadex LH-20柱色谱对该植物水溶性部位进行分离纯化,并通过光谱分析和文献对照确定化合物结构。结果从肾茶全草50%乙醇提取物中分离得到15个已知化合物,分别鉴定为(2S,E)-N-[2-羟基-2-(4-羟基苯乙基)]阿魏酸酰胺(Ⅰ)2、,6,2,′6′-四甲氧-基4,4′-二(2,3-环氧-1-羟基丙基)二苯(Ⅱ)、咖啡酸乙酯(Ⅲ)、催吐萝芙木醇(Ⅳ)、合欢布里苷O(albibrissinoside O,3-甲氧基-4-羟基-苯-1-O-β-[5-O-(3,5-二甲氧基-4-羟基-苯甲酸)]-呋喃芹菜糖基-(1→2)-O-β-吡喃葡萄糖苷,Ⅴ)、8-羟基-松脂醇(Ⅵ)、丁香脂素-4′-O-β-葡萄糖(Ⅶ)、1-羟基-丁香脂素(Ⅷ)、洋李苷(Ⅸ)、五叶山小橘苷C(glycopentoside C,3-甲氧基-4-羟基-苯-1-O-β-{5-O-[3-(2-(3-甲氧基-4-羟基-苯基)-3-羟甲基-7-羟基-2,3-二氢苯并呋喃-5-基)丙烯酸]}-呋喃芹菜糖基-(1→2)-O-β-吡喃葡萄糖苷,Ⅹ)、阿江榄仁葡萄糖苷I(arjunglucoside I,2α,3β,19α,23-四羟基-12-烯-28-齐墩果酸-28-O-β-吡喃葡萄糖苷,Ⅺ)、2,α3β,19,α23-四羟基-12-烯-28-齐墩果酸-23,28-O-β-二吡喃葡萄糖苷(ⅩⅡ)、大黄素(ⅩⅢ)、丁香脂素(ⅩⅣ)、(2S)-柚皮素(ⅩⅤ)。结论化合物Ⅰ~Ⅲ、Ⅵ~Ⅷ、Ⅹ~ⅩⅣ为首次从该植物中分离得到。更多还原

【Abstract】 Objective To study the water-soluble constituents of Clerodendranthus spicatus.MethodsCompounds were isolated by means of silica gel,ODS-A,Sephadex LH-20 column chromatographies.Their structures were identified by spectral methods and reference literature.Results Fifteen compounds were isolated from the 50% EtOH extract in the whole herb of C.spicatus.They were identified to be(2S,E)-N-[2-hydroxy-2-(4-hydroxyphenyl) ethyl] ferulamide(Ⅰ),2,6,2′,6′-tetramethoxy-4,4′-bis(2,3-epoxy-1-hydroxypropyl) biphenyl(Ⅱ),ethyl caffeate(Ⅲ),vomifoliol(Ⅳ),albibrissinoside B(Ⅴ),8hydroxypinoresinol(Ⅵ),syringaresinol-4′-O-β-glucopyranoside(Ⅶ),1-hydroxysyringaresinol(Ⅷ),prunin(Ⅸ),glycopentoside C(Ⅹ),arjunglucoside Ⅰ(Ⅺ),arjungenin-23,28-bis-O-glucopyranoside(Ⅹ Ⅱ),emodin(Ⅹ Ⅲ),syringaresinol(Ⅹ Ⅳ),and(2S)-naringenin(Ⅹ Ⅴ) on the basis of spectral analysis.Conclusion Among them,compounds Ⅰ—Ⅲ,Ⅵ—Ⅷ,and Ⅹ—Ⅹ Ⅳ are obtained from the title plant for the first time.更多还原