【摘要】 目的:研究普胃丸(巴豆、雄黄、豆蔻、陈皮、木香等)抗实验性胃溃疡的药效及镇痛作用。方法:采用大鼠水浸应激性、醋酸刺激性、幽门结扎性胃溃疡模型及小鼠利血平和无水乙醇诱发胃溃疡等实验方法,观察普胃丸抗胃溃疡的作用及其对胃液分泌、胃酸含量、胃蛋白酶活性的影响,以小鼠热板法及醋酸扭体法检测普胃丸的镇痛作用。结果:普胃丸能明显降低胃溃疡指数、抑制胃液分泌及降低胃蛋白酶活性,并能延长小鼠热刺激的痛阈时间,减少醋酸致痛小鼠扭体次数。结论:普胃丸具有明显的抗实验性胃溃疡作用,该作用与其抑制胃液、胃蛋白酶分泌,降低胃蛋白酶活性及镇痛作用有关。更多还原

【Abstract】 AIM: To explore Puwei Pill(Fructus crotonis,Realgar,Fructus amomi rotundus,Pericarpium citti reticulatae,Radix aucklandiae,etc)(PWP) pharmacodynamic action of resisting gastric ulcer. METHODS: The rat’s gastric ulcer models were induced by water-immersion stress,acetic acid,pyloric ligation.The gastric mucosa injure in mice was induced by absolute ethyl alcohol and reserpine,respectively.The ulcer was observed and the content of gastric juice,gastric acidity and the activity of pepsin were measured.The analgesic effect was tested by the hot-plate and torsive malposition in mice. RESULTS: PWP markedly reduced the gastric ulcer index,inhibited the secretion of gastric juice and decreased the activity of pepsin,alleviated the pain induced by acetic acid and raised hot pain threshold in mice. CONCLUSION: PWP has antigastric ulcer effect,which is relate to the inhibition of the secretion of gastric juice,the decrease in the activity of pepsin and the analgetic effect.更多还原