【摘要】 目的观察对氟康唑耐药的外阴阴道念珠菌病(VVC)白念珠菌对其他唑类药物的敏感性和交叉耐药性。方法用CLSI颁布的M27-A2方案检测氟康唑(FLC)、伊曲康唑(ITC)、伏立康唑(VRC)及联苯苄唑(B IF)对VVC分离的耐FLC白念珠菌的最低抑菌浓度(M IC)。结果19株VVC分离白念珠菌中有11株对FLC,ITC交叉耐药,有5株对FLC,ITC,VRC交叉耐药。结论VVC分离白念珠菌对唑类药物存在交叉耐药性,尤其在FLC与ITC之间明显。更多还原

【Abstract】 Objective To study sensitivities and cross-resistances of fluconazole-resistant Candida albicans isolates from vulvovaginal candidiasis to other azoles.Methods Minimum inhibitory concentration(MIC) of fluconazole,itraconazole,voriconazole and bifonazole were tested by utilizing Clinical Laboratory Standards Institute(CLSI) broth microdilution methods.Results Eleven of the total 19 FLC-resistant isolates showed cross-resistances to ITC,and 5/19 FLC-resistant isolates showed cross-resistances to both ITC and VRC.Conclusions Some of the fluconazole-resistant Candida albicans isolates could have cross-resistance to other common azole antifungal agents.更多还原