【摘要】 目的研究膝关节腔内联合运用罗哌卡因和新斯的明对膝关节镜术后镇痛效果。方法将40例膝关节镜手术患者分为Ⅰ组和Ⅱ组各20例,每组分别在术毕向膝关节腔内注入新斯的明0.5 mg+0.2%罗哌卡因30 m l(Ⅰ组),0.2%罗哌卡因30 m l(Ⅱ组),并进行镇痛效果评估。结果术后4小时和8小时,Ⅰ组VAS评分均明显低于Ⅱ组(P<0.05)。但在12、24、48小时VAS评分差异无显著性意义。结论新斯的明与罗哌卡因联用可明显增强术后8小时左右的镇痛效果。加快了起效时间,极少发生不良反应,是一种安全有效的膝关节手术后镇痛方法。更多还原

【Abstract】 Objective To evaluate the analgesic effect of intra-articular ropivacaine with neostigmine.Methods Forty patients receiving selective knee arthroscopy were randomized into two groups of 20 patients respectively.At the end of the operation,an intra-articular injection was administered to each patient through arthroscope.In accordance with their random allocation:100 mg ropivacaine and 0.5mg neostigimie(Ⅰgroup),and 100 mg ropivacaine along(Ⅱ group).Pain intensity was assessed after operation using the 100-mm visual-analog scale(VAS).Results The VAS scores of ropivacaine with neostigmine(Ⅰgroup)were significantly lower than ropivacaine alone(Ⅱ group)(P < 0.05) after postoperation time of 4 hours and 8 hours.Conclusions The combination of intra-articular neostigmine with ropivacaine can reduce the patients’ pain severity in 8 hours after surgery and have rare adverse reactions.更多还原