【摘要】 目的评价经蝶显微手术治疗垂体腺瘤的临床疗效。方法回顾性分析2001年1月至2008年6月经蝶显微手术治疗的526例垂体腺瘤患者的临床资料、影像学、内分泌及病理检查结果、肿瘤切除率、术后并发症以及随访结果。结果微腺瘤的肿瘤全切率85.4%,小腺瘤全切率61.9%,大腺瘤全切率70.0%,巨大腺瘤全切率38.1%;术后并发尿崩386例,均为暂时性尿崩;并发脑脊液漏65例,术后出血3例,感染2例,鼻出血3例;术后死亡2例,1例死于残余肿瘤出血,1例死于垂体功能低下;术后患者临床症状及内分泌功能有显著改善,辅以立体定向放射治疗后肿瘤复发率低(0.7%)。结论随着显微神经外科技术的日益成熟及新技术的应用,经单鼻孔蝶窦手术可安全、有效地治疗绝大部分垂体腺瘤。更多还原

【Abstract】 Objective To evaluate the effectivenees of the microsurgical resection of pituitary adenomas via the mononostril-septum-transsphenoidal approach.Methods The clinical presentation,image characteristics,endocrinal findings,pathological types,tumor removal percentage,postoperative complicationand follow-up of 526 patients with pituitary ademomas who underwent the transsphenoidal microsurgery from Jan 2001 to Jun 2008 were analysed retrospectively.Results Total tumor removal rate achieved 85.4% in the patients with microadenomas,61.9% in glandadenomas,70.0% in macroadenomas,and 38.1% in macrosisadenomas.A significant postoperative improvement both in clinical symptoms and endocrinal paraments was achieved.The tumor recurrencerate was 0.7%.Conclusions With the improvement of microsurgical technique and application of novel technique,the mononostril-septum-transsphenoidal microsurgery turn to be an effective and safe therapy for the resection of most Pituitary adenomas.更多还原