【摘要】 采用"一锅法"设计合成了9个N-硝基脲衍生物,收率50.2%~76.8%。通过红外光谱、核磁共振氢谱及元素分析等测试技术确证了它们的结构。初步抑菌活性测试表明,当质量浓度为50 mg/L时,各化合物对所测试菌种均表现出不同程度的抑菌活性。其中,化合物3d和3e对水稻纹枯菌的抑菌率超过50%。量化计算结果表明,分子中的脲桥是该类化合物的抑菌活性部位。更多还原

【Abstract】 Nine compounds of N-nitro urea were prepared by one pot method.The yields of products were in a range of 50.2%~76.8%.The structures of the compounds were identified by 1H NMR,IR and elemental analysis.Preliminary bacteriostatic activity tests show that all the compounds exhibited varying degrees of antibacterial activity on tested strains when the concentration was 50 mg/L;especially,the inhibitory rates of compounds 3d and 3e on Rhizoctonia Solani were over 50%.Quantum chemistry calculation results indicate that the urea-bridge in the compounds was the chemical active site for such bacteriostatic activity.更多还原