【摘要】 合成了一系列稳定高效的新型碳糖苷类熊果苷类似物,其中10个化合物未见文献报道。化合物结构通过核磁及质谱确证。初步生物活性测试结果表明,目标化合物具有良好的酪氨酸酶抑制活性,其中化合物13、14、15、16、19的活性接近或优于天然熊果苷。更多还原

【Abstract】 A series of stable and effective 4-hydroxyphenyl-D-glucopyranoside derivates were synthesized.The 10 new compounds were characterized by 1H NMR and HRMS.The preliminary test of bioactivity showed that they displayed notable inhibitions to tyrosinase.The inhibitions of compounds 13,14,15,16 and 19 to tyrosinase were equal or better than that of natural arbutin.更多还原