【摘要】 目的探讨草分枝杆菌对难治性结核性脑膜炎患者外周血中T淋巴细胞亚群的影响。方法选取2005年4月至2007年9月住院的未经抗结核治疗的难治性结核性脑膜炎患者84例,随机均分为两组。治疗组采用草分枝杆菌+HRZE+氟美松+鞘内注药方案,对照组仅用HRZE+氟美松+鞘内注药方案治疗,用药4周。结果治疗组临床疗效明显优于对照组;与治疗组比较,CD3+及CD4+细胞明显增加,CD8+细胞降低,CD4+/CD8+值显著升高(P<0.01)。结论草分枝杆菌对难治性结脑患者具有细胞免疫调节作用,疗效肯定,副作用小,是理想的抗结核辅助用药。更多还原

【Abstract】 Objective To investigate the effect of utilins on peripheral T-lymphocyte subsets in refractory tuberculous meningitis.Methods 84 inpatients of refractory tuberculous meningitis without antituberculosis treatment in April 2005 to September 2007,25 females and 59 males,aged 15-78 years,were selected and randomly divided into two groups.The treatment group was given utilins +HRZE +dexamethasone +intrathecal injection program,the control group was only given HRZE +dexamethasone +intrathecal injection program.The therapeutic courses all were 4 weeks.Results The effect in the treatment group was better than that in the control group.Compared with the treatment group,CD3+and CD4+markedly increased and CD8+decreased,the value of CD4+/CD8+obviously increased(P < 0.01).Conclusion Utllins treating refractory tuberculous meningitis has a role in cellular immune regulation with certain curative effect and less side effects.It is an ideal adjuvant anti-TB drug.更多还原