【摘要】 目的:观察氟哌啶-芬太尼合剂(氟芬合剂)、咪唑安定和异丙酚治疗291例全麻苏醒期躁动的疗效以及不良反应。方法:气管插管全麻导管拔除后发生躁动的291例患者随机分为对照组M组、P组,观察组FD组,每组97例。M组采用静脉注射咪唑安定0.06～0.10mg/kg,P组静脉注射异丙酚1.5～2.0mg/kg,FD组静脉注射氟哌利多-芬太尼合剂(氟哌利多0.05～0.10mg/kg,芬太尼1.0～2.0μg/kg)。观察三种方法治疗躁动的疗效、呼吸抑制(SpO2<90%)的程度以及治疗后再次清醒时间。结果:M组、P组和FD组控制躁动的有效率分别为61.86%、63.92%和88.66%,FD组明显高于其他两组(P<0.05)。三种方法引起呼吸抑制的发生率无显著性差异(P>0.05)。FD组和P组再次清醒的时间均明显早于M组(P<0.05),FD组和P组间无显著性差异(P>0.05)。结论:氟芬合剂治疗全麻苏醒期发生的躁动疗效高、苏醒快,副作用小,值得临床应用。更多还原

【Abstract】 Objective:To observe the curative efficacy and side-effect of 291 patients being pulled out tracheal canula during the recovery period emerging agitation with compound of Droperidol and Fentanly,Midazolam or Propofol.Methods:291 patients with emergence agitation during the recovery period,after had been pulled out the tracheal canula,were randomly divided into three groups,including two control groups(group M and group P) and an observational group(group FD),97 patients in each group.Patients in group M were injected with Midazolam(0.06-0.10 mg/kg),Propofol(1.5-2.0 mg/kg) in group P and with compound of Droperidol(0.05-0.10 mg/kg)and Fentanyl(1.0-2.0 μg/kg) in group FD.Then we observed the clinic curative efficacy on the emergence agitation,the incidence of respiratory inhibition(SpO2<90%) and the sober time after three different treatments.Results:The rate of curative efficacy in group M,group P and FD was 61.86%,63.92% and 88.63% respectively,the efficient rate in group FD was significantly higher than that of the other groups(P<0.05).The sober time after treatment in group FD and group P was earlier than that of group M(P<0.05) and there was no significant difference between group FD and group P(P>0.05).There was no difference in respiratory inhibition among three groups after treatment(P>0.05).Conclusion:The compound of Droperidol and Fentanly is the most effective method to treat the emergence agitation,which deserves clinic application on account of its high efficacy,quick regaining consciousness and little side-effect.更多还原