【摘要】 目的:观察药敏试验指导下的肝癌及肝癌腹腔积液化学治疗的治疗效果。方法:将性别、年龄与肿瘤类型、分期、腹腔积液量相同的肝癌患者配对,并将配对病例随机分入实验组与对照组。采用MTT法体外检测腹腔积液肿瘤细胞的药物敏感性,实验组选用含肿瘤抑制率较高药物的联合化疗方案,对照组采用联合应用5-氟尿嘧啶、顺铂、表阿霉素方案,对两组患者进行全身化疗和腹腔内化疗。结果:24对配对患者的研究结果显示,实验组腹腔积液治疗有效率为87.50%,对照组腹腔积液治疗有效率为70.83%,两组腹腔积液治疗有效率无显著性差异(P>0.05);实验组肿瘤治疗有效率为58.33%,对照组肿瘤治疗有效率为33.33%,实验组肿瘤治疗有效率高于对照组(P<0.05)。结论:药物敏感性试验指导下的肝癌化疗其肿瘤治疗的有效率高于常规方法用药。更多还原

【Abstract】 Objective:To observe the effect of the treatment with the chemotherapy selected by drug sensitivity assay in liver cancer and malignant ascites.Methods:The criteria of a matched-pair included patients’age,sex,stage of cancer and the amount of ascites.Patients of a matched-pair were selected into experimental group and control group randomly.Drug sensitivity was tested with MTT method.Patients of experimental group were treated with the chemotherapy selected by drug sensitivity assay,and the patients of control group were treated with combination therapy of 5-FU,DDP and Epirubicin.Re-sults:Among the 24 matched-pair patients,the ascites response rates of experimental group and control group were 87.50 % and 70.83% respectively,it showed no statistical difference between the two groups(P>0.05).Meanwhile the tumor response rate of experimental group was 58.33%,which was significantly higher than 33.33% of control group(P<0.05).Conclusion:The response rate of chemotherapy selected by drug sensitivity assay is higher than that of combination therapy of 5-FU, DDP and Epirubicin in liver cancer treatment.更多还原