【摘要】 目的探讨乙型肝炎病毒(HBV)感染相关性血小板减少性紫癜的临床及血液学、免疫学特点。方法对147例特发性血小板减少性紫癜(ITP)的患者临床资料进行回顾性分析。其中45例HBV阳性的ITP病例(A组)与同期102例HBV阴性的ITP病例(B组)比较包括血象、骨髓象、免疫学指标等。结果A、B两组比较,A组骨髓巨核细胞成熟停滞阶段处于更早阶段;两组外周血小板计数无统计学意义,但A组血红蛋白(Hb)、白细胞(WBC)计数较B组有较明显降低;两组血清免疫球蛋白(IgG、IgA、IgM),血小板相关抗体(PAIgG)比较无统计学意义。结论HBV感染与血小板减少有一定的相关性,是血小板减少的原因之一。更多还原

【Abstract】 ObjectiveTo study the clinical,hematological and immunologic features of hepatitis B virus(HBV)infection-associated thrombocytopenic purpura.MethodsThe clinical data of 147 patients with immune thrombocytopenic purpura(ITP)were retrospectively analyzed.The hemogram,bone marrow film,and immunologic tests of 45 HBV-positive cases(group A)were compared with those of 102 HBV-negative ones(group B)in the same period.ResultsComparing the two groups,the maturation of bone marrow megakaryocytes in group A was stagnant at an earlier stage;There was no statistical difference in peripheral platelet count between these two groups.However,the hemoglobin(Hb)and leukocyte(WBC)counts of group A were significantly lower than those of group B.There were no differences in serum immunoglobulin(IgG,IgA,IgM)and platelet-associated IgG(PAIgG)between them.ConclusionHepatitis B virus infection was related to thrombocytopenia,and it could be one of the important factors leading to the onset of ITP.更多还原