【摘要】 目的探讨低剂量国产干扰素(赛诺金)联合CHOPP方案治疗皮肤T细胞淋巴瘤(CTCL)的疗效及不良反应。方法1996年6月～2008年6月,采用低剂量国产干扰素(赛诺金)联合CHOPP方案治疗46例皮肤T细胞淋巴瘤患者,全部病例均接受至少4周期化疗。赛诺金300万U,im,qod;CTX600mg/m2,iv,d1;ADM50mg/m2,iv,d1;VCR1.4mg/m2,iv,d1;泼尼松90mg/d,顿服,d1～5;PYM8mg/d,im,d1、3、5,3周重复。化疗同时,皮损处涂抹盐酸氮芥溶液,每日1次。结果CR23例,PR16例,NC7例。有效率84.78%。生存时间最长11.6年,平均生存时间8.9±0.56年;主要不良反应为骨髓抑制和一次性发热。结论低剂量国产干扰素(赛诺金)联合CHOPP方案治疗皮肤T细胞淋巴瘤疗效肯定,毒不良反应小,值得临床推广应用。更多还原

【Abstract】 Objective To discuss the curative effects and side-effects of combining low-dose domestic interferon(sainuojin)with CHOPP-regimen in treating skin T-lymphoma.Method During the period June 1996 to June 2008,46 cases patient with skin T-lymphoma were treated by low-dose domestic interferon(sainuojin)and CHOPP-regimen,and all patient were received four cycle chemotherapy at least.And the usage was as follows:Sainuojin 3×106U/d,im,d1～21;CTX 600mg/m2,iv,d1;ADM 50mg/m2,iv,d1;VCR 1.4mg/m2,iv,d1;Predinisone 90 mg/d,PO,d1～5;PYM 8mg/d,im,d1,3,5,and every 3 weeks repeat.At the same time,the place of skin lesion was daubed with hydrochloric acid nitrogen mustard once everyday.Results CR 23 cases,PR 16 cases,NC 7 cases.The effective rate was 84.78%.The maximum time of survivorship was 11.6 years;the average survivorship time was 8.9±0.56 years;and the mostly side-effects were arrest of bone marrow and fever.Conclusion The curative effects of combining low-dose domestic interferon(sainuojin)with CHOPP-regimen in treating skin T-lymphoma were confirmed,and the side-effects were small.It is good for clinical popularization and application.更多还原