【摘要】 <正>由多因素诱发的失控性胃酸分泌及胃防御功能损害而引起的胃溃疡是严重的全球性问题。近年来,氧自由基在胃黏膜损伤中的作用日益受到重视。许多研究表明,氧自由基所致的细胞损害是很多病理更多还原

【Abstract】 This study is to investigate therapeutic effect of astaxanthin on acetic acid-induced gastric ulcer in rats.Rats were divided into control group,ulcer control group,and astaxanthin(5,10,and 25 mg.kg-1) groups at random,8 rats in each group.After administered for 10 days consecutively,all the rats were sacrificed.The area of ulcer and the levels of MDA,SOD,CAT and GSH-Px in gastric mucosa were measured.Compared with ulcer control group,in astaxanthin(5,10,and 25 mg.kg-1) groups,the area of ulcer was decreased significantly.Level of MDA decreased while activities of SOD,CAT and GSH-Px increased(P < 0.05).Astaxanthin has good therapeutic effect on acetic acid-induced gastric ulcer in rats.Eliminating free radical and improving local blood circulation of the ulcer may be the mechanism of action.更多还原