【摘要】 用125I标记示踪法研究大鼠皮下注射聚乙二醇化重组人生长激素(PEG-rhGH)药代动力学特征。大鼠scPEG-rhGH后,测定血清PEG-rhGH浓度,用3P97程序拟和分析并计算药代动力学参数。大鼠scPEG-rhGH150、300或600μg.kg-1后,药物消除符合一房室模型。经与相关文献比较可知,生长激素经PEG化修饰后能延长其在体内的作用时间,达到长效目的。更多还原

【Abstract】 To study the pharmacokinetics of rhGH decorated by polyethylene glycol(PEG-rhGH) after sc administration in rat,serum PEG-rhGH concentrations were measured by 125I labeled method after sc in rat,the pharmacokinetic model and parameters were fitted and calculated by the 3P97 program.After sc injection at doses of 150,300,and 600 μg.kg-1 in rat,the serum PEG-rhGH concentration-time curves were fitted to a one-compartment model.The rhGH decorated by polyethylene glycol could prolong the action duration of rhGH in vivo,and reach the goal of long-action.更多还原