【摘要】 目的评价热灌注化疗加免疫治疗机治疗恶性腹水的疗效及其毒副反应。方法60例恶性腹水患者随机分为对照组(单纯热灌注化疗),治疗组(热灌注化疗加免疫治疗系统)。对照组腹腔内灌注草酸铂,灌注后1 h内行局部热疗,42～43℃,每周2次。治疗组先行腹腔内热灌注化疗,方法同对照组,然后加免疫治疗系统治疗,每日1次,每次30 min,连续10 d。结果对照组有效率83%,治疗组有效率87%,两组比较无明显差异。两组的外周血白细胞增高率,对照组3.33%,治疗组16.67%,有显著性差异(P<0.05);KPS评分改善率对照组10%,治疗组30%,有显著性差异(P<0.05)。结论热灌注化疗加用免疫治疗系统治疗恶性腹水较单纯热灌注化疗疗效有提高,但对疗后血象及卡氏评分改善有明显作用。更多还原

【Abstract】 Objective To evaluate the effects and toxic side effects of the hyperthermic perfusion chemotherapy(HPC) combined with immune therapeutic system(ITS) for the treatment of malignant ascites.Methods Sixty cases of malignant ascites were randomly divided into treatment group(HPC+ ITS) and control group(HPC).LHP(42-43℃) was conducted in one hour in treatment group after L-OHP were inputted by peritoneocentesis,then the patients were treated with immune therapeutic system once a day(30 min,10 days).L-OHP were inputted by peritoneocentesis in control group without immune therapeutic system.Results The effective rate was 87% in treatment group and 83% in control group;there was no difference between the two groups(P>0.05).But on the increasing rate of white blood cell,there was 16.67% in treatment group and 3.33% in control group;there was difference between the two groups(P<0.05);KPS scale increasing rate was 30% in treatment group and 10% in control group;there was difference between the two groups(P<0.05).Conclusions The hyperthermic perfusion chemotherapy and immune therapeutic system was more efficient for malignant ascites than sole hyperthemic perfusion chemotherapy.There was obvious improvement in hemogram and KPS.更多还原