【摘要】 目的:观察枸杞多糖(lycium barbarum polysaccharide,LBP)对大鼠海马缺血再灌注损伤后超氧化物歧化酶(superoxide dismutase,SOD)的活性和白介素6(interleukin 6,IL-6)含量的影响。方法:选用健康成年SD大鼠,雌雄不拘,随机分成3组:对照组、缺血再灌注组和枸杞多糖组。脑缺血模型采用线栓法致大脑中动脉阻闭,2h后抽出栓塞线,再灌注24h后处死大鼠,测定海马SOD活性和IL-6的含量。结果:(1)枸杞多糖对缺血再灌注大鼠海马SOD活性的影响:缺血再灌注组大鼠海马SOD活性显著低于对照组(P<0.01),枸杞多糖组大鼠海马SOD活性低于对照组,但显著高于缺血再灌注组(P<0.01)。(2)枸杞多糖对缺血再灌注大鼠海马IL-6的影响:枸杞多糖组大鼠海马IL-6含量与正常对照组相比差异没有统计学意义,而与缺血再灌注组大鼠相比明显下降(P<0.05)。结论:枸杞多糖可提高缺血再灌注大鼠海马SOD活性,降低IL-6的含量,对缺血再灌注损伤有保护作用。更多还原

【Abstract】 Objective:To observe the effect of lycium barbarum polysaccharide(LBP) on superoxide dismutase(SOD) and interleukin 6(IL-6) in hippocampus of rats with ischemia-perfusion injury.Methods:Healthy adult SD rats were divided into three groups randomly: normal control group(C),ischemia-perfusion group(IR)and lycium barbarum polysaccharide group(LBP).Cerebral ischemia-perfusion model of rat was made by middle cerebral artery occlusion(MACO) with 3-0 nylon monofilament for 120 minutes.The activity of SOD and content of IL-6 in hippocampus of rats were detected after 24 hours reperfusion.Results:(1)Influence of LBP on the activity of SOD:activity of SOD in IR group was significantly lower than that of C group(P<0.01).The activity of SOD in LBP group was lower than that of C group,while higher than that of IR group significantly(P<0.01).(2)Influence of LBP on the content of IL-6: the content of IL-6 had no significant difference compared to that of C group and was lower than that of IR group(P<0.05).Conclusion:The study indicated that LBP could improve the activity of SOD and decrease the content of IL-6.LBP may relate with protection of ischemia-perfusion injury.更多还原