PLGA is a kind of biodegradable polymers used most widely to prepare microspheres with good biocompatibility.The double emulsion method is the often used technique for preparation of protein drugs loaded PLGA microspheres.The influences of formulation,procedure,etc. on the particle size,encapsulation efficiency and release profile of the microspheres and the stability of protein drugs in the preparation of protein drugs loaded PLGA microspheres by double emulsion method were reviewed.
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