【摘要】 目的:探讨辛伐他汀对高脂血症患者炎症因子单核细胞趋化蛋白-1(MCP-1)和血管内皮功能的影响。方法:选取高脂血症患者60例,采用双盲对照试验,把入选患者随机分为治疗组(n=30)和对照组(n=30),并以健康志愿者作为正常对照组(n=26)。对照组患者仅给予低脂饮食,治疗组在推荐低脂饮食基础上给予辛伐他汀20 mg/d,疗程8周。采用超声心动图仪检测血管内皮依赖性血流介导的舒张功能(FMD),采用酶联免疫吸附法(ELISA)检测MCP-1血清浓度。结果:高脂血症患者治疗前FMD显著低于正常对照组,MCP-1显著高于正常对照组。直线相关分析显示,MCP-1与FMD呈显著负相关(r=-0.562 0,P<0.001)。经8周辛伐他汀治疗后,治疗组患者的TC、LDL-C和MCP-1显著降低(P<0.05),FMD较治疗前显著增高。FMD的增高程度与TC、LDL-C降低程度无显著相关性(r=-0.110 0,0.022 0,P>0.05)。结论:辛伐他汀抗动脉粥样硬化作用可能部分与减少炎症因子MCP-1及改善血管内皮功能有关。辛伐他汀对高脂血症患者血管内皮依赖性舒张功能的改善可能部分独立于降脂作用。更多还原

【Abstract】 Objective:To investigate the effect of simvastatin on monocyte chemoattractant protein-1(MCP-1) and vascular endothelial function in patients with hyperlipidemia.Methods:Sixty patients with hyperlipidemia were randomly divided into treatment group(n=30) and control group(n=30).Twenty-six healthy subjects were chosen as the normal control group.Patients in control group were given low-fat diet,while those in treatment group were given simvastatin 20 mg/d based on low-fat diet.The therapy was lasted 8 weeks.Endothelial-dependent flow-mediated vasodilation(FMD) was determined by ultrasonic cardiograph.Serum concentrations of MCP-1 before and after the therapy were determined by ELISA method.Results:FMD of patients with hyperlipidemia was significantly lower and the serum concentrations of MCP-1 were significantly higher than those in the normal control group.FMD was negatively correlated to the levels of MCP-1(r=-0.562 0) in all patients with hyperlipidemia.After 8-weeks of treatment with simvastatin,the levels of TC,LDL-C and MCP-1 were decreased significantly(P<0.05) and FMD was increased.The reduction of TC or LDL-C levels was not correlated with the improvement of FMD.Conclusion:Anti-atherosclerotic effect of simvastatin may be partly related to the reduction of MCP-1 level and the improvement of vascular endothelial function.Simvastatin improves vascular endothelial function partly independent from its lipid-lowering effect.更多还原