【摘要】 目的:探讨抗肿瘤药物致过敏性休克的特点和规律。方法:采用回顾性研究方法,对江苏省2003年12月～2008年2月收集的26例抗肿瘤药物致过敏性休克病例报告进行综合分析。结果:抗肿瘤药物致过敏性休克涉及50岁以上的中老年人最多,紫杉醇、多西他赛、奥沙利铂居致休克药物的前三位;静脉用药不良反应发生比例最高,占96.15%;抗肿瘤药物以致速发型过敏性休克为主,占88.46%。结论:临床应加强对抗肿瘤药物致过敏性休克的预防和监测。更多还原

【Abstract】 Objective:To probe the characteristics and regularity of allergic shock induced by anticancer drugs. Method:In a retrospective case study,26 ADR/ADE reports of allergic shock induced by anticancer drugs were analyzed in Jiangsu province from December 2003 to February 2008.Result:The case reports displayed that the middle and old aged people were the main part in the reports.The incidence rates of allergic shock induced by paclitaxel,docetaxel and oxaliplatin occupied the front 3 places in sequence,and the drugs for intravenous administration resulted in the highest rate (96.15%).A large proportion of allergic shock was the immediate type(88.46%).Conclusion:Attention should be paid to allergic shock induced by anticancer drugs to ensure the safe and rational drug use.更多还原