【摘要】 目的:建立毛细管气相色谱法同时测定酚氨咖敏颗粒中对乙酰氨基酚、氨基比林、咖啡因和马来酸氯苯那敏的含量。方法:以无水乙醇为溶剂,样品无需衍生化处理,直接进样,用SE-30大口径毛细管色谱柱(30m×0.53mm,1.0μm),FID检测器,以盐酸麻黄碱为内标,进行测定。结果:对乙酰氨基酚、氨基比林、咖啡因和马来酸氯苯那敏的线性范围分别为20～2000μg·mL-1、15～1500μg·mL-1、10～500μg·mL-1、20～100μg·mL-1,各组分的平均回收率在98.9%～101.2%范围内,方法的精密度和稳定性良好,RSD<2%。结论:本法简便、快速、准确,可用于酚氨咖敏颗粒中对乙酰氨基酚、咖啡因、氨基比林和马来酸氯苯那敏的含量测定。更多还原

【Abstract】 Objective:To establish a gas chromatographic method for the determination of paracetamol,aminopyrine,caffeine,chlorphenamine maleate in paracetamol,aminophenazone phenacetin,caffeine and chlorphenamine maleate granules at the same time.Method:After the sample was dissovled in dehydrated alcohol and got filtered.Analysis the filtrate directly.The GC system included SE-30 wide bore capillary column (30 m×0.53 mm,1.0 μm) with flame ionization detector (FID),ephedrine hydrochloride was used as internal standard.Results:The linear range of paracetamol,aminopyrine,caffeine and chlorphenamine maleate was 20-2000 μg·mL-1,15-1500 μg·mL-1,10-500 μg·mL-1and 20-100 μg·mL-1,respectively;The average recoveries were 98.9%-101.2%;The precision and stability of the method were good,RSD < 2%.Conclusion:The method is convenient,rapid,accurate and reliable and may be adopted for assay of paracetamol,aminopyrine,caffeine and chlorphenamine maleate in paracetamol,aminophenazone phenacetin,caffeine and chlorphenamine maleate granules.更多还原