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多指标正交试验法优选杜仲药材最佳炮制工艺

Optimum stir-bake with saltwater technology on Cortex Eucommiae by multiple indexes orthogonal test

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【作者】 张萍张南平林瑞超

【Author】 ZHANG Ping,ZHANG Nan-ping,LIN Rui-chao(National Institute for the Control of Pharmaceutical and Biological Products,Beijing 100050,China)

【机构】 中国药品生物制品检定所

【摘要】 目的:采用多指标正交试验法优选杜仲药材最佳盐炙工艺,为规范杜仲药材的炮制工艺提供技术参数。方法:采用正交试验法,以炮制品中松脂醇二葡萄糖苷含量、乙醇浸出物的量、炮制品外观性状为指标,考察炮制温度、炮制时间及食盐的浓度三因素对杜仲盐炙工艺进行优选。结果:炮制温度对试验结果有显著影响,而炮制时间及盐浓度对试验结果无显著影响,综合考察各因素的影响,盐炙杜仲的最佳工艺为:每1 kg杜仲药材喷洒2%盐水溶液拌匀润透,150℃炒制10 min。结论:本研究对规范杜仲的盐炙炮制工艺具有一定的指导和参考意义。

【Abstract】 Objective:To optimize and establish stir-bake with saltwater technology on Cortex Eucommiae by multiple indexes orthogonal test methods and to provide technical index on standardization of stir-bake with saltwater on Cortex Eucommiae.Methods:The orthogonal test was employed to determine the effects of the three factors including the concentration of saltwater,temperature and stir-bake time affiliated with three factors of the determination of pinoresinol diglucoside,the determination of alcohol extractive and appearance characters.Results:Temperature had notable effect on experimental results,but stir-bake time and the concentration of saltwater had no notable effects on the results.Consider the effects of three factors synthetically,the temperature was at 150 ℃,stir-bake time was 10 min and adding 2% saltwater.Conclusion:The research is meaningful to standardization of stir-bake with saltwater on Cortex Eucommiae.

【基金】 国家科技支撑计划中药资源可持续利用与产业共性技术研究(编号:2006BAI09B06)
  • 【文献出处】 药物分析杂志 ,Chinese Journal of Pharmaceutical Analysis , 编辑部邮箱 ,2009年11期
  • 【分类号】R283
  • 【被引频次】11
  • 【下载频次】574
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