【摘要】 目的探讨血浆肿瘤坏死因子α(TNF-α)水平与非酒精性脂肪肝(NAFLD)及代谢综合征(MS)的关系及其可能的作用机制。方法将122例NAFLD患者分为非MS组(53例)和MS组(69例),另选择同期门诊健康体检人群(NS组)30例作为对照。通过放射免疫法测定三组血浆TNF-α水平并进行比较。结果①MS组血清TNF-α水平明显高于非MS组(P<0.05),且两组TNF-α水平均高于NS组(P<0.05);②NAFLD患者随着伴随MS组分数目的增多,血浆TNF-α水平进行性升高(P<0.05)。结论TNF-α参与NAFLD和MS的发生发展,是两者相互联结的炎症因子之一。更多还原

【Abstract】 Objective To investigate the correlation of tumor necrosis factor-alpha(TNF-alpha) and non-alcoholic fatty liver diseases(NAFLD) complicated with metabolic syndrome(MS) and its possible mechanism.Methods 122 patients with NAFLD were divided into non-MS group(n=53) and MS group(n=69),30 healthy subjects undergoing physical examination were enrolled in control group.A radioimmuodetection was used to measure TNF-alpha levels in three groups and compared among three groups.Results 1.TNF-alpha level of MS group was higher than that of non-MS group(P<0.05),TNF-a levels of both MS group and non-MS group were higher than that of NS group(P<0.05).2.Patients with NAFLD complicated with more risk factors of MS,plasma TNF-a levels elevated progressively(P<0.05).Conclusion TNF-alpha is involved in the genesis and development of NAFLD and MS,and is one of the inflammatory factors that link these two diseases.更多还原