节点文献
取代1,2,4-三唑并[1,5-c]嘧啶衍生物的合成与生物活性
Synthesis and Biological Activity of Substituted 1,2,4-Triazolo[1,5-c]pyrimidine Derivatives
【摘要】 以肼基取代嘧啶为起始原料,设计合成了16个新型的5-甲硫基-7-氯-1,2,4-三唑并[1,5-c]嘧啶-2-氧苄醚类及35个取代1,2,4-三唑并[1,5-c]嘧啶-2-氧苯醚类化合物,通过元素分析、MS和1HNMR对所合成的化合物进行了结构表征.初步生测结果表明,部分化合物表现出不同程度的除草及杀菌活性.
【Abstract】 Sixteen novel 2-[substituted benzyloxy 7-chloro-5-methylsulfanyl-[1,2,4]-triazolo[1,5-c] pyrimidine derivatives and thirty-six novel substituted 2-phenoxy-[1,2,4]-triazolo[1,5-c]pyrimidine deriva- tives have been designed and synthesized using substituted 4-hydrazinopyrimidine as starting material. All synthesized compounds were confirmed by elemental analysis, MS and 1H NMR techniques. Preliminary bioassay indicates that some of them display good herbicidal and fungicidal activities.
【关键词】 1,2,4-三唑并[1,5-c]嘧啶;
合成;
生物活性;
【Key words】 1,2,4-triazolo[1,5-c]pyrimidine; synthesis; biological activity;
【Key words】 1,2,4-triazolo[1,5-c]pyrimidine; synthesis; biological activity;
【基金】 国家自然科学基金(Nos.20702018,20572030,20528201);国家973前期专项(No.2007CB11630);教育部跨世纪优秀人才、教育部重点科技项目(No.104205);湖北省自然科学基金优秀群体(No.2004ABC002)资助项目
- 【文献出处】 有机化学 ,Chinese Journal of Organic Chemistry , 编辑部邮箱 ,2009年02期
- 【分类号】TQ450.2
- 【被引频次】14
- 【下载频次】433