【摘要】 目的研究螺旋CT双期增强扫描测定肾小球滤过率(GFR)的方法及其准确性,评估UroCARE软件计算GFR的可靠性。方法选择25例无急性肾功能障碍的成年患者,CT检查包括腹部平扫和双期增强扫描(动脉期、门静脉期),同时在动脉期前与两期之间各插入一组同层动态扫描。应用UroCARE软件计算GFR,以血清半胱氨酸蛋白酶抑制剂C(CystatinC)测定的GFR作为对照指标。结果两种方法测定的GFR相关性良好,r=0.799,y=39.0977+0.6083x。结论螺旋CT双期增强扫描并应用UroCARE软件可以较准确地测定GFR,具有一定的临床应用前景。更多还原

【Abstract】 Objective To investigate the technique and accuracy of dual-phase helical CT for measuring glomerular filtration rate(GFR),and evaluate the reliability of software UroCARE for determining GFR.Methods Twenty-five adult patients without acute renal disorder were included in this study.Each patient underwent CT for clinical indications.The CT protocol consisted of a plain examination and two contrast material-enhanced examinations in the arterial and portovenous phase.Seven dynamic scans were obtained before arterial phase,while four scans obtained between arterial and portovenous phase with reduced tube current every 2 seconds to obtain sufficient function data.CT clearance was calculated by software UroCARE.As a reference,cystatin C was determined in 25 blood specimens.Results Linear regression analysis showed that GFR of two groups was well correlated.The correlation coefficient of whole kidney was 0.799 and a regression line of y=39.0977+0.6083x.Conclusion GFR can be measured accurately with minimally extended dual-phase CT for patients without acute renal disorder.It is reliable in clinical practice to use the software UroCARE for determining GFR.更多还原