【摘要】 目的探讨曲马多用于剖宫产预防麻醉期间寒战和对新生儿的影响。方法ASAⅠ～Ⅱ级择期剖宫产手术产妇80例均分为4组,分别于麻醉前以30 mg/min的速度静脉预注曲马多0.5 mg/kg(A组)、1 mg/kg(B组)、1.5 mg/kg(C组),或注射0.9%氯化钠0.05 ml/kg(D组)。然后实施硬膜外麻醉。观察麻醉手术期间产妇的Wrench寒战分级和新生儿Apgar评分。结果B、C两组寒战发生率显著低于D组(90%vs.50%)(P<0.01);C组在娩出即刻、1-min和5-min Apgar评分均低于D组[(7.6±1.4 vs.9.2±0.5)、(8.3±1.2 vs.9.4±0.5)和(8.6±1.1 vs.9.6±0.4)](P<0.05)。结论麻醉前预注曲马多1.0或1.5 mg/kg能有效预防寒战的发生;1 mg/kg曲马多是一个适宜的剂量。更多还原

【Abstract】 Objective To investigate the effects of tramadol on the shivering and newborn in the patients undergoing Ceasarean section under epidural anesthesia.Methods Eigty patients were divided into 4 groups with 10 cases each.Tramadol 0.5mg/kg(group A),1.0mg/kg(group B),1.5mg/kg(group C),or normal saline 0.05ml/kg(group D) was injected IV.before anesthesia,which was followed by epidural blokade with rupivacaine.The shivering was evaluated by Wrench grading during operation and Apgar scores were recorded at 0,1 and 5min after born.Results The rate of shivwering was significantly higher in group B and C than that in group D(90% vs.50%)(P<0.01).Apgar scores at 0,1 and 5min were significantluy lower in group C than those in group D [(7.6±1.4 vs.9.2±0.5),(8.3±1.2 vs.9.4±0.5) and(8.6±1.1 vs.9.6±0.4),respectively](P<0.05).Conclusion Injection of tramadol 1.0mg/kg or 1.5mg/kg before anesthesia can effectively attenuate the shivwering,of which tramadol 1.0mg/kg is a reasonable choice without adverse effect on the newborn.更多还原