【摘要】 目的观察食管癌调强放疗(IMRT)中肺组织接受剂量,分析其相关因素,探讨食管癌放射治疗方案。方法采用Topslane Venus调强放疗系统,对29例首程治疗食管癌病人设计调强放射治疗计划,均做全组处方剂量60~68 Gy,在规定计划靶区(PTV)达到95%处方剂量,用剂量体积直方图(DVH)比较肺组织受照射时剂量体积与损伤关系,以及临床因素与肺损伤关系。结果在放射性肺损伤有关的因素:左肺最大剂量(Dmax)、平均剂量(Dmean)、肺V10、肺V20和肺V30中,左肺V20的参数差异有统计学意义(P<0.05),右肺V20、Dmean、Dmax的参数差异有统计学意义,而双肺Dmean、V30、V20的参数差异有统计学意义。结论剂量学因素可以较好地预测放射性肺损伤的发生。更多还原

【Abstract】 Objective To observe the influence of the doses of risk organs such as lungs to their functions in patients with esophageal cancer with IMRT.Methods To design IMRT plans which tumour dose were 60~68 Gy for 29 patients with esophageal cancer and analyze the relationships of injury of lungs the irradiated volume of them with DVH on the conditions of 95% turmor dose covers PTV.Results Dmean,V20 and V30 of right lung had significant difference for radioactivity injury of lungs in these pertinent factors such as Dmax,Dmean,V10,V20,V30;V20 of left lung had significant difference;Dmean,V20 and V30 of double lung had significant difference.Conclusion Dosimetry factor can predict well the occurrence of injury of lungs.更多还原