【摘要】 目的考察醇质体凝胶作为伊曲康唑透皮给药载体的可行性。方法采用注入法制备伊曲康唑醇质体进而用卡波姆制备成凝胶,采用透皮扩散试验仪对大鼠皮肤进行体外经皮渗透实验;以HPLC测定药物含量求算积累渗透量及稳态透皮速率,并测定药物在皮肤表皮和真皮中的滞留量。结果伊曲康唑醇质体凝胶的经皮渗透率是其水溶液的9.20倍,是体积分数为30%乙醇环糊精溶液的1.97倍。结论醇质体凝胶能提高伊曲康唑的透皮速率,增加药物在皮肤内的滞留量。更多还原

【Abstract】 Objective To investigate the feasibility of ethosmoe gel as transdemal carries of Itraconazole.Methods Itraconazole was encapsulated in ethosomes composed of phospholipids and ethanol,then ethosomes were incorporated in carbopol gel.Percutaneous permeation of Itraconazole was observed using rat skin and Franz transdermal diffusion device in vitro.The concentration of Itraconazole in receptor compartment at specified time points were determined by HPLC.The steady flux and the accumulation quantity of Itraconazole in epidermis and dermis were calculated.Results The flux of Itraconazole from ethosome gel were 9.20,and 1.97 times higher than that from aqueous solution,30% ethanol HP-β-CD solution gel preparation,respectively.Conclusion Ethosome gel is effective for transdemal delivery and increased the Itraconazole amount retained in the skin.更多还原