【摘要】 目的探讨加替沙星滴眼液单次滴兔眼后在角膜中的药动学特征。方法24只新西兰家兔,局部滴入加替沙星滴眼液50μl,以高效液相色谱法测定兔眼角膜中加替沙星的药物浓度,用DAS1.0软件计算药动学参数。结果给药后0.5~6 h,加替沙星在兔眼角膜中的最高浓度为(3.18±1.39)μg/g,消除半衰期(t1/2)为(2.33±0.58)h,药-时曲线下面积AUC0~6h为(7.40±2.07)μg/(h.g)。空白角膜不干扰加替沙星的含量测定。结论加替沙星滴眼液单次滴兔眼后在眼角膜中具有良好的药动学特征和组织通透性。更多还原

【Abstract】 Objective To study pharmacokinetics of gatifloxacin in ocular cornea of rabbit after ocular instillation.Methods Eyes of 24 New England rabbits’ were topically applied 50 l of gatifloxacin eye drops.Ocular cornea were sampled at different intervals after drug instillation,and the drug levels were assayed by HPLC.The pharmacokinetics parameters were figured out by DAS 1.0 process.Results The peak concentration of gatifloxacin in cornea was(3.18±1.39) g/g,The half-lives of elimination was(2.33±0.58) h.The AUC0～6hwere(7.40±2.07) μg/(h·g).Blank cornea did not interfere with the determination of gatifloxacin.Conclusion Gatifloxacin has a good pharmacokinetics character and permeability in ocular cornea of rabbit.更多还原