【摘要】 胞质中的乙二醛酶系能有效去除胞内α-羰基醛类化合物的细胞毒性,对细胞具有重要的保护作用,乙二醛酶Ⅰ是该酶系的关键酶。α-羰基醛是体内形成晚期糖基化终末产物(AGEs)的主要活性中间体。α-羰基醛和AGEs都能促进阿尔采末病(AD)的发生和发展。因此乙二醛酶Ⅰ的表达和酶活性水平与AD病变具有非常重要的关系。更多还原

【Abstract】 Glyoxalase system,a most effective defence system is present in cytosol of cells to scavenge α-oxoaldehydes,which are reactive intermediates of AGEs formation.Glyoxalase Ⅰ is the key enzyme of this system.α-oxoaldehydes and AGEs are involved in the development of Alzheimer′s disease (AD). Therefore,the expression level and activity of glyoxalase I are essential to pathogenesis of AD.更多还原