【摘要】 目的调查和分析我院抗铜绿假单胞菌感染药物使用情况,提高临床使用抗菌药物的合理性。方法回顾性调查铜绿假单胞菌感染病人107例(188株铜绿假单胞菌),分析抗菌药物使用情况。采用药物利用评价的方法计算用药频度(DDDs)。主要依据《抗菌药物临床应用指导原则》判断用药合理性。结果研究发现易感人群以老年、伴发多种基础疾病、住院时间长的病人居多,临床感染类型主要以肺部感染和尿路感染为主。DDDs排列前6位的分别是哌拉西林-三唑巴坦,头孢哌酮-舒巴坦,头孢米诺,美罗培南,左氧氟沙星和环丙沙星。结论我院治疗铜绿假单胞菌感染以选择β-内酰胺酶抑制剂复合制剂为主,临床工作中应重视易感人群的病原学监测以指导用药、控制感染,并加强抗菌药物合理使用的管理。更多还原

【Abstract】 AIM To investigate and analyse the use of anti-bacterial agents for Pseudomonas aeruginosa infection in our hospital and provide the guide to the rational use of antibiotics.METHODS A retrospective study on 188 strains of Pseudomonas aeruginosa identified from different specimens from 107 patients with Pseudomonas aeruginosa infection provided by our hospital.Medication frequency was assessed by drug use evaluation methods to get understanding of the drug use tendency of clinicians.Reasonable evaluation of drug use was according to the Clinical Use of Antibiotics Drug Designated Evaluation Principles.RESULTS Pseudomonas aeruginosa infection mostly happened in aged patients,patients associated with variety of underlying diseases,and the patients in long length of stay.Most common types of infection were lung infection and urinary tract infection.In terms of Defined Daily Dose System,piperacillin /tazobactam,cefoperazone /sulbactam,cefminox sodium,meropenem,levofloxacin,and ciprofloxacin were the top six.CONCLUSION In our hospital,most Pseudomonas aeruginosa infections were administrated β-lactamase inhibitors.It is necessary to pay more attention to the pathogen inspection of susceptible population to control infection,and reinforce the management of rational use of drug.更多还原