【摘要】 目的评价2007年长江流域6城市157家医院β-内酰胺类抗生素临床应用状况。方法对入网医院目前临床应用的β-内酰胺类品种,分别以通用名称和商品名称的用药金额、通用名称的用药频度进行排序。结果2007年6城市β-内酰胺类用药总金额已达28.8亿元,较上年度增长了31.0%,该类药物占全部抗感染药物比例平均达57.5%。在6城市的用药金额排名榜中,位居前列的主要为头孢呋辛、头孢米诺钠、头孢哌酮舒巴坦和头孢匹胺等。DDDs排名则显示,青霉素类的阿莫西林及其复合酶制剂为该区域临床抗感染选择频率较高的品种。结论β-内酰胺加酶复方制剂在长江流域的使用已经比较普遍,临床应严格掌握其适应证为治疗产β-内酰胺酶细菌感染,严防不合理用药加速细菌耐药发生。更多还原

【Abstract】 AIM To evaluate the clinical utilization of β-lactam antibiotics in 157 hospitals of 6 main cities in the Yangtze River valley in 2007.METHODS According to the orders of sum of total expenditure approved drug name and trade name,and Defined Daily Dose(DDDs);the β-lactams antibiotics used in the clinic were analysed.RESULTS The total annual cost of the β-lactam used in 157 hospitals was 2.88 billion yuan in 2007,approximately 31.0% more than that of the year before and nearly to the average 57.5% of all anti-infection medicines.In the column of demonstrated,cefuroxime,cefminox sodium,cefoperazone sulbactam and cefpiramide were the predominant main antibiotics.But the column of DDDs indicated that amoxicillin and amoxicillin-lactamase inhibitor were the most frequently selected drugs for curing the infection diseases in the area.CONCLUSION β-lactam / β-lactamase inhibitor complex combination preparations have been used extensively.But strict application to infection caused by β-lactamase bacterium is necessary to avoid the microbial drug resistance.更多还原