【摘要】 目的:探讨前列腺特异抗原(prostate specific antigen,PSA)、前列腺特异性抗原密度(prostate specific antigen density,PSAD)及移行带前列腺特异性抗原密度(pros-tate specific antigen density of transition zone,PSAD-TZ)用于前列腺癌筛选时前列腺体积和患者年龄因素对其的影响。方法:回顾性分析因PSA升高和(或)直肠指检异常疑诊前列腺癌而进行直肠前列腺穿刺活组织检查(活检)的295例男性患者的临床资料,根据活检结果分为BPH组(193例)和前列腺癌组(102例),比较2组中不同前列腺体积以及不同年龄段的PSA、PSAD及PSAD-TZ水平。结果:当前列腺体积小于或等于50mL时,BPH组的PSA、PS-AD及PSAD-TZ值与前列腺癌组比较差异均有统计学意义(P<0.01);当前列腺体积大于50mL时,2组的PSA值比较差异无统计学意义(P>0.05),但PSAD及PSAD-TZ值比较差异有统计学意义(均为P<0.01)。2组的PSA值随着年龄的增加而升高(均为P<0.01)。在50～59岁者和60～69岁者中,2组的PSAD及PSAD-TZ值比较差异均有统计学意义(P<0.05～0.01);在70～79岁者中,2组的PSAD及PSA-TZ值比较差异无统计学意义。结论:当前列腺体积小于或等于50mL时,检测PSA、PSAD及PSAD-TZ值对前列腺癌的筛选有重要意义,而前列腺体积大于50mL时,需结合PSAD、PSAD-TZ值以及患者的年龄作综合分析。更多还原

【Abstract】 Objective:To study the influence of prostate volume(PV)and patients’ age on prostate specific antigen(PSA),prostate specific antigen density(PSAD)and prostate specific antigen density of transition zone (PSAD-TZ)in screening prostate cancer. Methods:The clinical data of 295 male patients were restrospectively analyzed,which with elevated PSA and / or abnormal digital examination. Transrectal prostate biopsies were performed to diagnose prostate cancer. Based on the results of biopsy,two groups were defined: benign prostate hyperplasia(BPH)group(193 cases)and cancer group(102 cases). PSA,PSAD,and PSAD-TZ were assessed according to different prostate volume and patients’age in two groups. Results:When prostate volume was ≤50 mL,statistically significant differences in PSA,PSAD and PSAD-TZ were noted between BPH group and cancer group(P<0.01). When prostate volume was >50 mL,no significant difference in PSA(P>0.05)was found,but there were significant differences in PSAD and PSAD-TZ(P<0.01)between the two groups. PSA values increased with agein both groups(P<0.01). Significant differences in PSAD and PSAD-TZ were noted in age group from 50 to 59 year and age group from 60 to 69 year(P<0.05～0.01),but no significant difference was found in age group from 70 to 79 year. Conclusion:When prostate volume is ≤50 mL,detection of PSA,PSAD and PSAD-TZ is significant in screening prostate cancer. However,when prostate volume is >50 mL,age should be taken into consideration for PSAD and PSAD-TZ in screening prostate cancer.更多还原