【摘要】 目的:对百消散的急性毒性和亚急性毒性进行初步研究。方法:采用最大耐受量测定法及30d连续给药法分别观察其急性毒性和亚急性毒性。结果:急性毒性试验表明,百消散对雌、雄性小鼠急性经口给药LD50分别为10.8 g/kg和9.26 g/kg。亚急性毒性试验结果显示,0.35 g/kg及以上剂量组动物试验一周后活动减少,体重增加缓慢,被毛蓬松无光泽;雌、雄大鼠的体重及增重、食物利用率、脾/体重系数、肾上腺/体重系数、胸腺/体重系数、白细胞总数(WBC)、血红蛋白(HGB)、丙氨酸氨基转移酶(ALT)、总蛋白(TP)、白蛋白(ALB)、胆固醇(TC)等检测参数与对照组比较,均有极显著性差异(P<0.01);甘油三脂(TG)、肌酐(CRE)与对照组比较差异无显著性(P>0.05)。病理组织学检查可见胃粘膜贲门处复层扁平细胞增生明显,表皮角化明显。部分粘膜有炎症反应,表现为炎症细胞浸润,血管扩张。结论:亚急性毒性试验结果显示,百消散可引起动物的体重、肝肾功能、血常规、脏器系数等检测指标的改变,且有一定剂量-反应关系,对此应作进一步研究。更多还原

【Abstract】 Object:To observe the acute and sub-acute toxic effects of Bai-xiao-san(BXS).Method:we adopted maximally tolerated dosage in acute toxicity tests in mice and successive administration 30d for sub-acute toxicity tests in rats.Result:The acute toxicity showed a dose-dependent increase after oral administration of BXS in mice.The LD50 was observed at 10.8 g/kg and 9.26 g/kg,respectively.sub-acute toxic effects shows that after given dosage above0.35 g/kg a week,the movement of mice reduced,weight increased slowly,skin showed no smooth.The weight and increased weight,food availability,spleen/body-mass index,adrenal/body-mass index,thymus/ body-mass index,WBC,WGB,ALT,TP,ALB,TC had significant difference compared to control group(P<0.01);TG,CRE showed no differece to control group(P>0.05).Accrementition of flat cell was seen through histopathologic examination at gastric mucosa cardia,scarfskin cuticularizate obviously,part of membrana mucosa had Inflammatory reaction.Conclusion:The study shows that at common dosage BXS would not cause drug interaction.However,at high dosages it exhibited marked damage to all the major organs of the body.更多还原