【摘要】 目的:探讨环氧合酶-2(COX-2)及核因子-κB(NF-κB)在宫颈癌组织中的表达及意义。方法:采用免疫组织化学法检测COX-2和NF-κB在68例宫颈癌组织及20例正常宫颈组织中的表达。结果:COX-2在宫颈癌组织和正常宫颈组织中的表达率分别为43例(63.24%)和3例(15%),差异有显著性(χ2=14.41,P<0.01)。NF-κB在宫颈癌组织和正常宫颈组织中的表达率分别为49例(72.06%)和2例(10%),差异有显著性(χ2=24.43,P<0.01)。宫颈癌组织中的COX-2与NF-κB表达明显高于正常宫颈组织,且与淋巴结转移、病理分级和临床分期有关,与患者年龄及组织类型无关。结论:COX-2和NF-κB在宫颈癌的发生发展过程中起着重要作用。更多还原

【Abstract】 Objective:To investigate the expression and significance of COX-2 and NF-κB in cervical cancer.Methods:Immunohistochemical method was applied to examine the expression of COX-2 and NF-κB,in 20 normal and 68 cervical cancer tissues.Results: COX-2 was detected in 43 of 68(63.24%) cervical cancer tissues,but 15% in normal cervix tissues;the expression of COX-2 in the two groups was significantly different(χ2=14.41,P<0.01);NF-κB was detected in 49 of 68(72.06%) cervical cancer tissues,but 10% in normal cervix tissues;the expression of NF-κB in the two groups was significantly different(χ2=24.43,P<0.01).COX-2 and NF-κB expression in cervical cancer tissues was significantly higher than that in normal cervical tissues,and was associated with clinical stage,pathological grade,lymph node metastasis,but not associated with patient’s age and histological type.Conclusion:COX-2 and NF-κB may play an important role in the oncogenesis and development of cervical carcinoma.更多还原