【摘要】 评估在年轻患者和老年病患者中存在的药物治疗问题的频率与类型分布规律。102例患者分为两组(年轻组<65岁,老年组≥65岁),分别对其所患疾病、药物治疗情况和药物治疗问题进行统计学分析。入组标准:接受医生治疗和接受临床药师评估的患者。排除标准:未能或拒绝临床药师评估的患者。1)年轻组与老年组平均每人分别有3种或5种疾病,疾病与年龄有显著相关性(P<0.01);2)年轻组与老年组平均分别正在接受4种或7种药物治疗,老年组明显接受更多的药物治疗(P<0.01);3)在102例患者中共发现7大类85例药物治疗问题;4)36.8%的年轻组患者出现1～4例药物治疗问题,61.8%的老年组患者出现1～5例药物治疗问题,老年组明显出现更多药物治疗问题(P<0.05);5)两组患者所出现的药物治疗问题在类别上无显著性差异,但药物治疗不足是主要问题(年轻组占53.6%,老年组占54.6%)。无论年轻人还是老年人,均需要接受足够的药物治疗;与年轻患者相比,老年患者经历更多的药物治疗问题,应在临床药学实践中给予更多的关注。更多还原

【Abstract】 We evaluated the frequency and category distribution of drug therapy problems in young and elderly patients.A retrospective study of the medical conditions,drug therapies,and drug therapy problems identified in 102 patients was performed. The patients were divided into young patient group(<65 years of age) and elderly patient group(≥65 years of age) in a hospital pharmacy setting.Inclusion criteria:patients who were referred by the treating doctors and received evaluation by the clinical pharmacists.Exclusion criteria:patients who were unable to or refused to be evaluated by the clinical pharmacists.We found that 1) Patients in young and elderly groups had a mean of 3 and 5 medical conditions per person,respectively(P = 0.001).2) On the average,they took 4 and 7 drug therapies per person,respectively.The elderly patients took a significantly higher number of drug therapies(P = 0.001).3) Totally 85 drug therapy problems in 7 categories were identified within 102 patients.4) 36.8%of young patients experienced 1 to 4 drug therapy problems whereas 61.8%of elderly patient experienced 1 to 5 drug therapy problems. Drug therapy problems were significantly more prevalent in elderly patients(P = 0.017).5) The drug therapy problem by category had similar distribution in young and elderly patients.The elderly patients in this study encountered more drug therapy problems than young patients.Accordingly,more attention should be paid to elderly patients in pharmaceutical care practice.更多还原