【摘要】 目的探讨黄芩水提物对干酵母致热大鼠解热作用机制。方法建立干酵母致大鼠发热动物模型,观察黄芩水提物对发热大鼠直肠温度的影响,放免法测定大鼠下丘脑环磷酸腺苷(cAMP)、白细胞介素-1β(IL-1β)及脑腹中隔区精氨酸加压素(AVP)、血清IL-1β含量。结果黄芩水提物能够显著降低干酵母致热大鼠下丘脑IL-1β、cAMP的含量及腹中隔区脑组织AVP的含量,与模型组比较,P<0.05;各组大鼠的最大体温上升高度与下丘脑IL-1β、cAMP含量以及腹中隔区脑组织AVP的含量成正相关关系(P<0.05)。结论黄芩水提物可减少致热性细胞因子IL-1β在体温中枢的含量,减少中枢发热介质cAMP的含量,促进中枢解热介质AVP的释放。更多还原

【Abstract】 Objective To research the mechanism of aqueous extract of Radix Scutellariae in relieving fever of model rats. Method The fever model rats were made by dry yeast. Rectum temperature (ΔT/℃) was observed, and serum IL-1β, hypothalamus cAMP and IL-1β, ventral septal area AVP were detected by RIA. Results Aqueous extract of Radix Scutellariae decreased IL-1β and cAMP content of hypothalamus, and AVP content of ventral septal area significantly (compared with model group, P<0.05). There were positive correlativity between maximum height of temperature and IL-1β, cAMP content of hypothalamus, and AVP content of ventral septal area (P<0.05). Conclusion Radix Scutellariae can decrease the content of IL-1β and cAMP in temperature center, and advance the releasing of AVP.更多还原