【摘要】 目的确定鸦胆子油亚纳米乳注射液的处方和制备工艺。方法以精制鸦胆子油为油相,蛋黄卵磷脂和泊洛沙姆188为复合乳化剂,优选了鸦胆子油、乳化剂和稳定剂的用量,并用正交设计优化了制备工艺。结果最优处方为10%油相,1.2%乳化剂,0.1%稳定剂;最优工艺为水相和油相在70℃混合,10000r/min高速剪切20min,在900bar压力下高压均质6次。结论制得的鸦胆子油亚纳米乳注射液物理稳定性良好。更多还原

【Abstract】 Objective To optimize the prescription and technology of Brucea javanica oil subnanoemulsion injection. Methods Using superfine Brucea javanica oil as oil phase,yolk lecithin and poloxamer 188 as the complex emulsifying agents. The dosage of oil,emulsifier and stabilizer were optimized and the preparation was optimized by orthogonal experiments. Results The optimum precription was 10% oil phase,1.2% emulsifier and 0.1% stabilizer. The optimum technology was that aqueous phase and oil phase mixed at 70 ℃,sheared 20 min by high speed shearing machine and then passed the ultra-high pressure nano homogenizer 6 times under the pressure of 900 bar. Conclusion The physical stability of Brucea javanica oil subnanoemulsion injection is good.更多还原