【摘要】 目的:探讨氯化镧对实验性高脂血症大鼠脂质过氧化和内皮素1(ET-1)的调节作用。方法:50只SD大鼠随机被均分成5组,即对照组、高脂组、低剂量氯化镧组、中剂量氯化镧组、高剂量氯化镧组。对照组大鼠喂普通饲料,高脂组大鼠喂高脂饲料,其余各组大鼠喂高脂饲料并给予不同剂量氯化镧(0.1mg/kg、2mg/kg、40mg/kg)干预。12周后检测大鼠血脂及血浆超氧化物歧化酶(SOD)、丙二醛(MDA)、总抗氧能力(T-AOC)、一氧化氮(NO)、内皮素(ET)-1的变化。结果:与对照组相比,高脂组血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL-C)水平显著升高,高密度脂蛋白(HDL-C)显著降低,血浆MDA和ET-1水平明显增高,而SOD、T-AOC活性和NO水平明显降低(P<0.05～<0.01)。低剂量氯化镧组SOD、T-AOC、NO水平较高脂组显著升高,MDA、ET-1水平较高脂组明显降低(P<0.05～<0.01),中、高剂量组的各项指标与高脂组无显著差异。结论:低剂量氯化镧能明显提高抗氧化能力,抑制脂质过氧化,改善血管内皮细胞功能。更多还原

【Abstract】 Objective:To study the adjustment effects of LaCL3 on lipid-hyperoxidation and vascular endothelium function in hyperlipidemia model rats.Methods:Fifty SD rats were randomly equally divided into 5 groups:control group,hyperlipidemia group,low dose of LaCL3 group (0.1 mg/kg),middle dose of LaCL3 group (2 mg/kg) and high dose of LaCL3 group (40mg/kg).Rats were fed with high fat diet except control group and the intervention tests were carried out meanwhile.After 12 weeks,blood lipid profile,the level of malondialdehyde (MDA),nitric oxide (NO),total anti-oxidant capability(T-AOC),ET-1 and Superoxide dismutase (SOD) activities were assessed.Results:The level of serum total cholesterol (TC),triglyceride (TG),low density lipoprotein (LDL-C),MDA and ET-1 of hyperlipidemia rats were all higher than those in control group.HDL-C,NO,T-AOC level and SOD activities were lower than those in control group(P<0.05～<0.01).Compared with hyperlipidemia group,Low dose of LaCL3 increased NO,T-AOC level and SOD activities,conversely it decreased the level of MDA and ET-1 in plasma(P<0.05～<0.01).Conclusion:Low dose of LaCL3 enhanced the antioxidation,inhibited the lipid peroxidation and improved the vascular endothelium function.更多还原