【摘要】 目的:探讨辛伐他汀联用氢氯吡格雷对急性冠脉综合症患者高敏C反应蛋白(hs-CRP)及血脂的影响。方法:117例急性冠脉综合征患者被分成辛伐他汀常规治疗组(48例)和辛伐他汀联用氢氯吡格雷组(69例)。观察治疗后6周两组血浆hs-CRP和血脂含量的变化。结果:两组患者治疗后6周血浆hs-CRP、血脂水平均显著下降(P<0.01),但辛伐他汀联用氢氯吡格雷组的hs-CRP下降幅度较辛伐他汀组更大(P<0.05),两组血脂改善无显著差异(P>0.05)。结论:辛伐他汀联用氢氯吡格雷应用于急性冠脉综合征患者,能更有效地降低血浆hs-CRP浓度,更有利于抑制炎症、稳定斑块。更多还原

【Abstract】 Objective:To investigate the effects of simvastatin combined with clopidogrel on high sensitivity C-reactive protein(hs-CRP) and blood lipids in patients with acute coronary syndrome(ACS).Methods:A total of 117 patients with ACS were divided into two groups: simvastatin group(48 patients) and simvastatin combined with clopidogrel group(69 patients).The levels of hs-CRP and blood lipids were detected before and six-week after treatment.Results:The hs-CRP and blood lipids levels of patients significantly decreased in two groups(P<0.01 all).Compared with simvastatin group,the hs-CRP levels significantly decreased(P<0.05),but the blood lipids levels had not significant decreased(P>0.05)in simvastatin combined with clopidogrel group.Conclusion:Treatment with simvastatin combination with clopidogrel not only decrease the blood lipids levels but also has the best effects on lowering hs-CRP.It suggest that it may inhibit inflammatory responses,increase atherosclerotic plaque stabilization in ACS patients.更多还原