【摘要】 目的:探讨妊娠相关血浆蛋白A(PAPP-A)。高敏C反应蛋白(hs-CRP)与经皮冠状动脉介入治疗(PCI)术后再狭窄的关系。方法:选择71例接受PCI治疗并于PCI术后6个月复查冠脉造影的患者,经冠脉造影证实出现支架内再狭窄的患者14例(再狭窄组),未出现再狭窄的患者57例(无再狭窄组),测定入选患者PCI术前和术后血浆PAPP-A,hs-CRP水平并分析其支架内再狭窄情况。结果:再狭窄组患者术后血浆PAPP-A,hs-CRP水平较无再狭窄组显著升高(P<0.01),且术后PAPP-A,hs-CRP水平与PCI术后冠脉后期内径丢失指数呈正相关(r=0.57,P<0.01)。结论:PCI术后血浆PAPP-A,hs-CRP水平可以预测冠脉再狭窄的发生。更多还原

【Abstract】 Objective:To investigate the relationship between plasma pregnancy-associated plasma protein-A(PAPP-A),high sensitivity C-reactive protein(hs-CRP) and restenosis after percutaneous coronary intervention(PCI).Methods:A total of 71 patients performed PCI and followed by repeated angiography 6 months after PCI were selected.Their baseline and follow-up angiograms were compared by quantitative coronary angiography to assess incidence of restenosis.They were assigned in restenosis group(n=14)and no restenosis group(n=57)by angiography.Plasma PAPP-A and hs-CRP were measured before and after PCI.Results:The level of plasma PAPP-A and hs-CRP in restenosis group were significantly higher than that in no restenosis group after PCI(P<0.01).The later loss index of coronary artery lumen diameter was positive correlated with plasma PAPP-A and hs-CRP after PCI(r=0.57,P<0.01).Conclusion:Plasma PAPP-A and hs-CRP level after PCI possibly forecasts the occurrence of restenosis after PCI.更多还原