【摘要】 目的:探讨连续血液净化(CBP)治疗严重心力衰竭的临床价值。方法:我院2005年8月到2008年6月收治的61例严重心力衰竭患者被随机分为两组,对照组采用常规治疗,即使用速尿、西地兰、血管紧张素转换酶抑制剂(ACEI)等进行治疗;治疗组在对照组常规治疗基础上加用床旁CBP治疗12～48 h。两组患者于治疗前和一周后同时监测血压、中心静脉压(CVP)、心率、呼吸、血气分析和血生化;治疗1个月后评价心功能改善情况、左室射血分数(LVEF)、6 min步行试验(6-MWT)。结果:治疗1周后,治疗组的临床症状改善(呼吸,心率),血生化指标(血钠、血肌酐),血氧饱和度及氧分压,CVP等的改善明显优于对照组(P<0.01);1个月后,心功能改善总有效率(93.6%∶56.7%)、6-MWT[(392.5±36.1)m∶(276.3±41.5)m]和LVEF[(39.6±5.8)%∶(35.2±4.2)%]改善亦明显优于对照组(P<0.01)。结论:连续血液净化是治疗严重心力衰竭的有效方法,能较快改善心肺功能,维持水电解酸碱平衡,提高患者生存质量。更多还原

【Abstract】 Objective:To study the effect of continuous blood purification(CBP) in the treatment of severe heart failure.Methods:A total of 61 patients with serious heart failure were randomly divides into two groups:the control groups(used the conventional treatment) and treatment group(adds the CBP nearby bed for 12~48 h based the convention treatment of control group).Patients of two groups were simultaneously monitors the blood pressure,central venous pressure(CVP),heart rate and blood biochemistry indexes etc.before and one week after therapy.The heart function was evaluated one month after therapy.Results:Compared with control group,one week after therapy the clinical symptoms(breath,heart rate),blood biochemistry indexes,blood oxygen degree of saturation,oxygen partial pressure and the CVP more improved(P<0.01);one month after therapy the total effectiveness of heart function(56.7%∶93.6%)、6-MWT[(276.3±41.5) m∶(392.5±36.1) m] and LVEF[(35.2±4.2)%∶(39.6±5.8)%] also more improved(P<0.01) in treatment group.Conclusion:Continuous blood purification is an effective method in treatment of severe heart failure.更多还原