【摘要】 雌激素及其受体对绝经后妇女心血管系统疾病的病理生理有多方面的影响,包括高血压、心肌肥厚、心力衰竭、冠状动脉粥样硬化、心肌缺血、心肌梗死以及血脂、凝血纤溶系统等。早期的回顾性研究表明雌激素对绝经后女性的心血管有保护作用,但是最近的前瞻性临床研究结果却未能证明这一点,甚至提示弊大于利。因此引起了人们对雌激素替代疗法的争议。与此同时寻找更具安全性的雌激素替代疗法成为目前研究热点。相信,随着基础、临床研究的更加深入,人们将进一步认识雌激素及其受体的作用机制,并将最大程度地发挥雌激素替代治疗的"利"而缩小其"弊"。更多还原

【Abstract】 Estrogen and estrogen receptors show multiple effects on the pathophysiology of cardiovascular system diseases in postmenopausal women,including hypertension,myocardial hypertrophy,heart failure,coronary artery atherosclerosis,myocardial ischemia,myocardial infarction,serum lipids profile,and the fibrinolysis coagulation system.Early retrospective studies have shown that estrogen could prevent cardiovascular disease in postmenopausal women.However,recent prospective clinical research has failed to show the expected effects,and the results revealed that more harm than good may be caused.Therefore,estrogen replacement therapy is attracting more attention.Meanwhile,there is now a search for safe estrogen replacement therapies.In order to further our basic and clinical research we will need further understanding of the mechanism of estrogen and estrogen receptors on cardiovascular system in order to exact the maximum benefit and reduce the side effects.更多还原