【摘要】 心肌肥厚是心脏为适应血流动力学过负荷而发生的增生,它最终将导致心力衰竭,甚至猝死。心肌肥厚是许多心脏疾病发展的一个重要阶段,但是它的形成机制到现在还没有完全清楚。近年研究表明相关的信号通路主要集中在MAPK通路,Ca2+及其依赖的信号转导通路,磷脂酰肌醇-3激酶及其介导的信号转导通路和JAK/STAT信号通路等几条,并且信号通路之间相互联系。更多还原

【Abstract】 Cardiac hypertrophy is a functionally useful adaptation in response to haemodynamic overload.Hypertrophy is associated with an increased rate of sudden deaths.Cardiac hypertrophy is an important phase in heart disease development,but so far its molecular mechanism is not clear.Recent studies indicate that there are several signal pathways related to cardiac hypertrophy,including the mitogen-activated protein kinase pathway,the(MAPK)pathways,Ca2+ and its dependent signal pathways,phosphoinositide 3-kinase(PIP3),and its mediated signal pathway,and Janus kinase/signal transducer and activator of transcription signal pathway.Intercommunication was also observed between these signal pathways.更多还原