【摘要】 目的:探讨氯诺昔康与芬太尼联合用于下肢手术术后疼痛的镇痛效果及不良反应。方法:60例择期行下肢手术的患者术后随机分为硬膜外镇痛组(Ⅰ组)和静脉镇痛组(Ⅱ组)。以视觉模拟评分(VAS)作为疼痛强度指标,观察开始镇痛后不同时间点(4、12、24、48 h)两组患者的镇痛效果;记录镇痛期间的不良反应发生情况;镇痛结束后,统计患者对镇痛治疗的总体满意度。结果:开始镇痛后4、12、24、48 h VAS及镇静评分组间比较无统计学差异(P>0.05),镇痛结束后患者对镇痛治疗的总体满意度差异亦无统计学意义(P>0.05);Ⅱ组恶心、呕吐、轻度呼吸抑制(SpO2<95%)发生率明显低于Ⅰ组(P<0.05)。结论:氯诺昔康复合芬太尼用于下肢手术术后镇痛,效果确切,不良反应发生率低。更多还原

【Abstract】 Objective: To study the analgesic efficacy and side effects of lornoxicam combined with fentanyl used for lower limbs operation.Methods: Sixty patients underwent selective lower limbs operation were divided randomly into epidural anesthesia group(group Ⅰ) or patient-controlled intravenous analgesia group(group Ⅱ).Visual analogue score(VAS) was selected as the index of pain-intensity.4,12,24,48 h analgesic efficacy after the beginning of analgesia,the adverse effects during analgesia period were observed.Results: VAS at 4,12,24,48 h during analgesia,patients′ overall satisfaction on analgesia therapy were not different between two groups(P>0.05).The percentage of nausea,vomiting and mild respiration depression(SpO2<95%) were lower significantly in group Group Ⅱ than that in groupⅠ(P<0.05).Conclusion: Lornoxicam combined with fentanyl for analgesia after lower limbs operation could reduce side effects for postoperative analgosia.更多还原