【摘要】 矿化胶原是骨牙结缔组织中的基本结构单元。从材料学角度认识其组装机理是研发骨牙再生材料的基础和前题。概述了近年来围绕矿化胶原的分级结构和自组装机理的研究进展,以及在此基础上的仿生合成所取得的成果。重点说明目前对胶原生物矿化机理的了解程度以及尚在探索中的重要课题。从这项研究也可看到生物材料,特别是组织工程框架材料和再生医学工程中仿生思路的重要性。更多还原

【Abstract】 Mineralized collagen fibril is the basic structural unit of connective tissue in bone and tooth.Current understanding of the structure,self-assembly mechanisms,and properties of mineralized collagen fibril composites in connective tissues is reviewed.Recent work involving biomimetic synthesis of new materials with the structure of mineralized collagen is described.The research mainly focuses on materials containing type I collagen with mineralization by Ca-P crystals,although some other systems are also described.Development of bone grafts based on the mineralization of self assembled collagen fibrils in vivo and in vitro is active in research.This kind of bone graft composite has already shown great promise and success in clinical applications because of its compositional and structural properties similar to that of autologous bone.更多还原